NCDM-32B
NCDM-32B is a potent and selective KDM4 inhibitor, with IC50 values of 3.0 μM for KDM4A and 1.0 μM for KDM4C in in vitro enzyme assays. NCDM-32B specifically increases global H3K9me3/me2 levels in basal breast cancer cells. NCDM-32B impairs the viability of KDM4C-amplified basal breast cancer cell lines (HCC1954 and Colo824) . NCDM-32B can be used for the study of breast cancer[1][2].
Product Specifications
CAS Number
[1239468-48-4]
UNSPSC
12352211
Hazard Statement
H302, H315, H319, H335
Target
Histone Demethylase
Type
Reference compound
Related Pathways
Epigenetics
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ncdm-32b.html
Purity
97.0
Solubility
Ethanol : 25 mg/mL (ultrasonic; warming)
Smiles
O=C(CCN(O)C(CCCCCCCCN(C)C)=O)OC
Molecular Formula
C15H30N2O4
Molecular Weight
302.41
Precautions
H302, H315, H319, H335
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
KDM4
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