NCDM-32B

NCDM-32B is a potent and selective KDM4 inhibitor, with IC50 values of 3.0 μM for KDM4A and 1.0 μM for KDM4C in in vitro enzyme assays. NCDM-32B specifically increases global H3K9me3/me2 levels in basal breast cancer cells. NCDM-32B impairs the viability of KDM4C-amplified basal breast cancer cell lines (HCC1954 and Colo824) . NCDM-32B can be used for the study of breast cancer[1][2].

Product Specifications

CAS Number

[1239468-48-4]

UNSPSC

12352211

Hazard Statement

H302, H315, H319, H335

Target

Histone Demethylase

Type

Reference compound

Related Pathways

Epigenetics

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/ncdm-32b.html

Purity

97.0

Solubility

Ethanol : 25 mg/mL (ultrasonic; warming)

Smiles

O=C(CCN(O)C(CCCCCCCCN(C)C)=O)OC

Molecular Formula

C15H30N2O4

Molecular Weight

302.41

Precautions

H302, H315, H319, H335

References & Citations

[1]Ye Q, et al. Genetic alterations of KDM4 subfamily and therapeutic effect of novel demethylase inhibitor in breast cancer. Am J Cancer Res. 2015 Mar 15;5 (4) :1519-30.