VU6001966

VU6001966 (compound 15m) is a potent and cross the blood-brain barrier mGlu2 (metabotropic glutamate receptor 2) negative allosteric modulator with IC50s of 78 nM and >30 µM for mGlu2 and mGlu3, respectively. VU6001966 can serve as an mGlu2 PET tracer[1].

Product Specifications

CAS Number

[2009052-76-8]

UNSPSC

12352005

Target

MGluR

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/vu6001966.html

Purity

99.89

Solubility

DMSO : 10 mg/mL (ultrasonic)

Smiles

O=C(C1=NC=C(OCC2=NN(C)C=C2)C(C3=CC=C(F)C=C3)=C1)N

Molecular Formula

C17H15FN4O2

Molecular Weight

326.33

References & Citations

[1]Bollinger KA, et al. Design and Synthesis of mGlu2 NAMs with Improved Potency and CNS Penetration Based on a Truncated Picolinamide Core. ACS Med Chem Lett. 2017 Aug 3;8 (9) :919-924.