BMS-823778 (hydrochloride)
BMS-823778 hydrochloride is a potent, selective and orally active 11β-HSD1 inhibitor with an IC50 of 2.3 nM against human 11β-HSD1[1].
Product Specifications
CAS Number
[1140898-87-8]
UNSPSC
12352005
Hazard Statement
H302-H315-H319-H335
Target
11β-HSD
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/bms-823778-hydrochloride.html
Solubility
10 mM in DMSO
Smiles
CC(O)(C1=CC=CN2C1=NN=C2C3(C4=CC=C(Cl)C=C4)CC3)C.Cl
Molecular Formula
C18H19Cl2N3O
Molecular Weight
364.27
Precautions
P261-P280-P302+P352
References & Citations
[1]Li J, et al. Discovery of Clinical Candidate BMS-823778 as an Inhibitor of Human 11β-Hydroxysteroid Dehydrogenase Type 1 (11β-HSD-1) . ACS Med Chem Lett. 2018 Nov 13;9 (12) :1170-1174.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 2
Curated Selection
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