BMS-814580
BMS-814580 is an orally active, highly efficacious MCHR1 inhibitor with a Ki of 16.9 nM against hMCHR1. BMS-814580 shows antiobesity activities[1].
Product Specifications
CAS Number
1197420-11-3
UNSPSC
12352005
Target
MCHR1 (GPR24)
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/bms-814580.html
Solubility
10 mM in DMSO
Smiles
O=C1C2=C(N=CN1C3=CC=C(OCC4(O)CC(C4)(F)F)C(OC)=C3)C=C(S2)C5=CC=C(C=C5)Cl
Molecular Formula
C24H19ClF2N2O4S
Molecular Weight
504.93
References & Citations
[1]Ahmad S, et al. Synthesis and Antiobesity Properties of 6- (4-Chlorophenyl) -3- (4- ((3,3-difluoro-1-hydroxycyclobutyl) methoxy) -3-methoxyphenyl) thieno[3,2-d]pyrimidin-4 (3H) -one (BMS-814580) : A Highly Efficacious Melanin Concentrating Hormone Receptor 1 (MCHR1) Inhibitor. J Med Chem. 2016 Oct 13;59 (19) :8848-8858.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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