Welcome to GenPrice! Check out our latest updates.

Shopping Cart (0)

Your cart is empty

Add some products to get started!

JNc-440

Product Specifications

UNSPSC Description

JNc-440 is a potent antihypertensive agent. JNc-440 can enhance the interaction of TRPV4 and Ca2+-activated potassium channel 3 (KCa2.3) in endothelial cells. JNc-440 can also enhance vasodilation, and exerted antihypertensive effects in mice[1].

Target Antigen

Potassium Channel; TRP Channel

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel;Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/jnc-440.html

Purity

98.04

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

O=C(C(N1)=NC2=C(C=CC=C2)C1=O)NCCCNC(C(C3=CC=CC=C3)C4=CC=CC=C4)=O

Molecular Weight

440.503

References & Citations

[1]He D, et al. Treatment of hypertension by increasing impaired endothelial TRPV4-KCa2.3 interaction. EMBO Mol Med. 2017 Nov;9(11):1491-1503.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Product Datasheet

http://file.medchemexpress.com/batch_PDF/HY-120514/JNc-440-DataSheet-MedChemExpress.pdf

Product MSDS

http://file.medchemexpress.com/batch_PDF/HY-120514/JNc-440-SDS-MedChemExpress.pdf

Clinical Information

No Development Reported

CAS Number

1119503-63-7

Curated Selection

Explore Other Products

Discover premium biology products from our extensive collection of 20M+ items

ACO2 Antibody
A76362-100UL 100 µL

ACO2 Antibody

Ask
View Details
TMEM207 Human shRNA Lentiviral Particle (Locus ID 131920)
TL307968V 500 µL Each

TMEM207 Human shRNA Lentiviral Particle (Locus ID 131920)

Ask
View Details
Recombinant Puromycin Sensitive Aminopeptidase (PSA)
SIPE299Hu02-01 10 µg

Recombinant Puromycin Sensitive Aminopeptidase (PSA)

Ask
View Details
Recombinant Puromycin Sensitive Aminopeptidase (PSA)
SIPE299Hu02-02 50 µg

Recombinant Puromycin Sensitive Aminopeptidase (PSA)

Ask
View Details
Recombinant Puromycin Sensitive Aminopeptidase (PSA)
SIPE299Hu02-03 200 µg

Recombinant Puromycin Sensitive Aminopeptidase (PSA)

Ask
View Details
Recombinant Puromycin Sensitive Aminopeptidase (PSA)
SIPE299Hu02-04 1 mg

Recombinant Puromycin Sensitive Aminopeptidase (PSA)

Ask
View Details