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BMS-200

BMS-200 is a potent PD-1/PD-L1 interaction inhibitor with an IC50 of 80 nM. BMS-200 can induce dimerization of PD-L1[1].

Product Specifications

CAS Number

[1675203-82-3]

UNSPSC

12352005

Target

PD-1/PD-L1

Type

Reference compound

Related Pathways

Immunology/Inflammation

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/bms-200.html

Purity

98.02

Solubility

DMSO : 10 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O=C(O)C[C@H](O)CNCC1=CC(F)=C(OCC2=CC=CC(C3=CC=C(OCCO4)C4=C3)=C2C)C=C1F

Molecular Formula

C27H27F2NO6

Molecular Weight

499.50

References & Citations

[1]Katarzyna Guzik, et al. Small-Molecule Inhibitors of the Programmed Cell Death-1/Programmed Death-Ligand 1 (PD-1/PD-L1) Interaction via Transiently Induced Protein States and Dimerization of PD-L1. J Med Chem. 2017 Jul 13;60 (13) :5857-5867.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Product Datasheet

http://file.medchemexpress.com/batch_PDF/HY-120402/BMS-200-DataSheet-MedChemExpress.pdf

Product MSDS

http://file.medchemexpress.com/batch_PDF/HY-120402/BMS-200-SDS-MedChemExpress.pdf

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Curated Selection

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