LUF7346
LUF7346 is a potent Kv11.1 (hERG) channel negative allosteric modulator, with an IC50 of 35.6 ± 3.2 nM[1].
Product Specifications
CAS Number
[1821638-40-7]
UNSPSC
12352005
Target
Potassium Channel
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/luf7346.html
Solubility
10 mM in DMSO
Smiles
O=C(NC1=CC=CN=C1)COC2=CC=C(C(C3=CC=CC=C3Br)=O)C=C2
Molecular Formula
C20H15BrN2O3
Molecular Weight
411.25
References & Citations
[1]van Veldhoven JPD, et al. Targeting the Kv11.1 (hERG) channel with allosteric modulators. Synthesis and biological evaluation of three novel series of LUF7346 derivatives. Eur J Med Chem. 2021 Feb 15;212:113033.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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