LL-Z1640-4

LL-Z1640-4 is a potent p38/JNK signaling inhibitor. LL-Z1640-4 significantly diminishes p38 and JNK activation in HCC cells transfected with MLK4 siRNA. LL-Z1640-4 markedly attenuates ROS production induced by MLK4 knockdown. LL-Z1640-4 significantly reduces the apoptotic cells in HCC cells transfected with siMLK4[1][2].

Product Specifications

CAS Number

[66018-41-5]

UNSPSC

12352005

Target

Apoptosis; JNK; p38 MAPK; Reactive Oxygen Species (ROS)

Type

Reference compound

Related Pathways

Apoptosis; Immunology/Inflammation; MAPK/ERK Pathway; Metabolic Enzyme/Protease; NF-κB

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/ll-z1640-4.html

Purity

99.0

Solubility

10 mM in DMSO

Smiles

O=C1OC(C/C=C/C(C(C(C/C=C/C2=C1C(O)=CC(OC)=C2)O)O)O)C

Molecular Formula

C19H24O7

Molecular Weight

364.39

References & Citations

[1]Ellestad George A, et al. New zearalenone related macrolides and isocoumarins from an unidentified fungus. The Journal of Organic Chemistry, 1978,43 (12) :2339–2343.|[2]Li Y, Zuo H, Wang H, Hu A. Decrease of MLK4 prevents hepatocellular carcinoma (HCC) through reducing metastasis and inducing apoptosis regulated by ROS/MAPKs signaling. Biomed Pharmacother. 2019 Aug;116:108749.