CFI-400437
CFI-400437 is an indolinone-derived, ATP-competitive kinase inhibitor with high selectivity for PLK4 (IC50 of 0.6 nM) [1].
Product Specifications
CAS Number
1169211-37-3
UNSPSC
12352005
Target
Polo-like Kinase (PLK)
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/cfi-400437.html
Solubility
10 mM in DMSO
Smiles
O=C1NC2=C(C=C(OC)C=C2)/C1=C\C3=CC4=C(C=C3)C(/C=C/C5=CC=C(N6CCN(C)CC6)N=C5)=NN4
Molecular Formula
C29H28N6O2
Molecular Weight
492.57
References & Citations
[1]Radoslaw Laufer, et al. The discovery of PLK4 inhibitors: (E) -3- ((1H-Indazol-6-yl) methylene) indolin-2-ones as novel antiproliferative agents. J Med Chem. 2013 Aug 8;56 (15) :6069-87.|[2]Amreena Suri, et al. Evaluation of Protein Kinase Inhibitors with PLK4 Cross-Over Potential in a Pre-Clinical Model of Cancer. Int J Mol Sci. 2019 Apr 29;20 (9) :2112.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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