CFI-400437

CFI-400437 is an indolinone-derived, ATP-competitive kinase inhibitor with high selectivity for PLK4 (IC50 of 0.6 nM) [1].

Product Specifications

CAS Number

[1169211-37-3]

UNSPSC

12352005

Target

Polo-like Kinase (PLK)

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/cfi-400437.html

Solubility

10 mM in DMSO

Smiles

O=C1NC2=C(C=C(OC)C=C2)/C1=C\C3=CC4=C(C=C3)C(/C=C/C5=CC=C(N6CCN(C)CC6)N=C5)=NN4

Molecular Formula

C29H28N6O2

Molecular Weight

492.57

References & Citations

[1]Radoslaw Laufer, et al. The discovery of PLK4 inhibitors: (E) -3- ((1H-Indazol-6-yl) methylene) indolin-2-ones as novel antiproliferative agents. J Med Chem. 2013 Aug 8;56 (15) :6069-87.|[2]Amreena Suri, et al. Evaluation of Protein Kinase Inhibitors with PLK4 Cross-Over Potential in a Pre-Clinical Model of Cancer. Int J Mol Sci. 2019 Apr 29;20 (9) :2112.