CYD-2-11
CYD-2-11 is a selective Bax agonist with a Ki value of 34.1 nM. CYD-2-11 induces cell apoptosis and shows antiproliferative activity to breast cancer MDA-MB-231 and MCF-7 cell lines with IC50 values of 3.22 and 3.81 μM, respectively. CYD-2-11 suppresses tumor growth in MDA-MB-231 tumor models. CYD-2-11 can be used for the research of breast and lung cancer[1][2].
Product Specifications
CAS Number
1425944-22-4
UNSPSC
12352005
Target
Apoptosis; Bcl-2 Family
Type
Reference compound
Related Pathways
Apoptosis
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/cyd-2-11.html
Solubility
10 mM in DMSO
Smiles
NCCOC1=CC=CC=C1/C=C2C3=C(C=CC([N+]([O-])=O)=C3)C4=C/2C=CC=C4
Molecular Formula
C22H18N2O3
Molecular Weight
358.39
References & Citations
[1]Liu G, et al. Structure-activity relationship studies on Bax activator SMBA1 for the treatment of ER-positive and triple-negative breast cancer. Eur J Med Chem. 2019 Sep 15;178:589-605.|[2]Li R, et al. Modulation of Bax and mTOR for Cancer Therapeutics. Cancer Res. 2017 Jun 1;77 (11) :3001-3012. doi: 10.1158/0008-5472.CAN-16-2356. Epub 2017 Apr 5.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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