17 (R) -HDHA
17 (R) -HDHA (17 (R) -HDoHE) is a pro-resolving mediator (SPM) . 17 (R) -HDHA enhances the differentiation of B cells toward the CD27 (+) CD38 (+) antibody-secreting cell phenotype, thereby strongly increasing IgM and IgG production by activated B cells. 17 (R) -HDHA does not affect cell proliferation and is non-toxic to cells[1].
Product Specifications
CAS Number
155976-53-7
Product Name Alternative
17 (R) -HDoHE
UNSPSC
12352211
Hazard Statement
H225, H350
Target
Drug Derivative
Type
Reference compound
Related Pathways
Others
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/17-r-hdha.html
Concentration
290.28 μM * 1 mL in Ethanol
Purity
98.0
Solubility
10 mM in DMSO
Smiles
CC/C=C\C[C@@H](O)/C=C/C=C\C/C=C\C/C=C\C/C=C\CCC(O)=O
Molecular Formula
C22H32O3
Molecular Weight
344.49
Precautions
H225, H350
References & Citations
[1]Ramon S, et al. Specialized proresolving mediators enhance human B cell differentiation to antibody-secreting cells. J Immunol. 2012 Jul 15;189 (2) :1036-42.
Shipping Conditions
Blue Ice
Storage Conditions
Solution, -20°C, 2 years
Scientific Category
Natural Products
Clinical Information
No Development Reported
Available Sizes
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