Z-VRPR-FMK
Z-VRPR-FMK is an irreversible MALT1 protein inhibitor. Z-VRPR-FMK inhibits the growth and invasion of diffuse large B-cell lymphoma by inhibiting MALT1-induced NF-κB activation and MMP expression[1].
Product Specifications
CAS Number
1381885-28-4
UNSPSC
12352005
Target
MALT1
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease; NF-κB
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/z-vrpr-fmk.html
Purity
99.91
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(OCC1=CC=CC=C1)N[C@@H](C(C)C)C(N[C@@H](CCCNC(N)=N)C(N2[C@@H](CCC2)C(N[C@H](C(CF)=O)CCCNC(N)=N)=O)=O)=O
Molecular Formula
C31H49FN10O6
Molecular Weight
676.78
References & Citations
[1]Jianglong Feng, et al. Z-VRPR-FMK can inhibit the growth and invasiveness of diffuse large B-cell lymphoma by depressing NF-κB activation and MMP expression induced by MALT1. Int J Clin Exp Pathol. 2019 Jun 1;12 (6) :1947-1955. |[2]Lorena Fontan, et al. MALT1 small molecule inhibitors specifically suppress ABC-DLBCL in vitro and in vivo. Cancer Cell. 2012 Dec 11;22 (6) :812-24.
Shipping Conditions
Blue Ice
Storage Conditions
-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)
Scientific Category
Peptides
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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