Vatalanib (hydrochloride)
Product Specifications
UNSPSC Description
Vatalanib (PTK787; ZK-222584; CGP-797870) hydrochloride is an inhibitor of VEGFR2/KDR with an IC50 of 37 nM[1].
Target Antigen
Apoptosis; VEGFR
Type
Reference compound
Related Pathways
Apoptosis;Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Others; Cancer
Assay Protocol
https://www.medchemexpress.com/vatalanib-hydrochloride.html
Solubility
10 mM in DMSO
Smiles
ClC1=CC=C(NC2=NN=C(CC3=CC=NC=C3)C4=C2C=CC=C4)C=C1.[H]Cl
Molecular Weight
383.27
References & Citations
[1]Wood JM, et al. PTK787/ZK 222584, a novel and potent inhibitor of vascular endothelial growth factor receptor tyrosine kinases, impairs vascular endothelial growth factor-induced responses and tumor growth after oral administration. Cancer Res. 2000;60(8):2178-2189.|[2]Murakami M, et al. Tyrosine kinase inhibitor PTK/ZK enhances the antitumor effects of interferon-α/5-fluorouracil therapy for hepatocellular carcinoma cells. Ann Surg Oncol. 2011;18(2):589-596.|[3]Wan J, et al. Local recurrence of small cell lung cancer following radiofrequency ablation is induced by HIF-1α expression in the transition zone. Oncol Rep. 2016;35(3):1297-1308.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-12018A/Vatalanib-hydrochloride-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-12018A/
Clinical Information
Phase 3
CAS Number
212141-52-1
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
![E74 like factor 1 (ELF1) Mouse Monoclonal Antibody (Biotin conjugated) [Clone ID: OTI3G7]](https://cdn.genprice.uk/genprice/genprice3.png)
TA811207AM 100 µL
E74 like factor 1 (ELF1) Mouse Monoclonal Antibody (Biotin conjugated) [Clone ID: OTI3G7]
Ask
View Details 