Vatalanib (hydrochloride)

Vatalanib (PTK787; ZK-222584; CGP-797870) hydrochloride is an inhibitor of VEGFR2/KDR with an IC50 of 37 nM[1].

Product Specifications

CAS Number

[212141-52-1]

Product Name Alternative

PTK787 (hydrochloride) ; ZK-222584 (hydrochloride) ; CGP-797870 (hydrochloride)

UNSPSC

12352005

Target

Apoptosis; VEGFR

Type

Reference compound

Related Pathways

Apoptosis; Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Others; Cancer

Assay Protocol

https://www.medchemexpress.com/vatalanib-hydrochloride.html

Solubility

10 mM in DMSO

Smiles

ClC1=CC=C(NC2=NN=C(CC3=CC=NC=C3)C4=C2C=CC=C4)C=C1.[H]Cl

Molecular Formula

C20H16Cl2N4

Molecular Weight

383.27

References & Citations

[1]Wood JM, et al. PTK787/ZK 222584, a novel and potent inhibitor of vascular endothelial growth factor receptor tyrosine kinases, impairs vascular endothelial growth factor-induced responses and tumor growth after oral administration. Cancer Res. 2000;60 (8) :2178-2189.|[2]Murakami M, et al. Tyrosine kinase inhibitor PTK/ZK enhances the antitumor effects of interferon-α/5-fluorouracil therapy for hepatocellular carcinoma cells. Ann Surg Oncol. 2011;18 (2) :589-596.|[3]Wan J, et al. Local recurrence of small cell lung cancer following radiofrequency ablation is induced by HIF-1α expression in the transition zone. Oncol Rep. 2016;35 (3) :1297-1308.