What is the catalog number for Inotodiol?

The catalog number for Inotodiol is HY-120149.

What sizes are available for Inotodiol?

Inotodiol is available in the following size(s): 1 mg, 5 mg, 10 mg.

How many pack sizes does Inotodiol come in?

Inotodiol is available in 3 different pack sizes.

Is Inotodiol in stock?

Inotodiol is currently made to order / not held in immediate stock. Contact us for lead time.

Who manufactures Inotodiol?

Inotodiol is manufactured by QuantiMol.

What is the estimated delivery time for Inotodiol?

Estimated delivery time for Inotodiol is approximately 15 business day(s), depending on your location.

Where can I find the safety data sheet (SDS/MSDS) for Inotodiol?

The safety data sheet for Inotodiol is available here: http://file.medchemexpress.com/batch_PDF/HY-120149/Inotodiol-SDS-MedChemExpress.pdf.

Inotodiol

Inotodiol activates p53 signaling pathway, inhibits MMP-2/9, and exhibits antitumor activity in cancer cell HeLa. Inotodiol inhibits the generation of ROS and exhibits antioxidant and neuroprotective effects. Inotodiol inhibits the activation of MAPK and NF-κB signaling pathway, and exhibits anti-inflammatory activity. Inotodiol inhibits TLR-4 mediated TNF-α production (IC50s in BMMC and BMDM is 0.7 μM and 3.0 μM), inhibits the degranulation in mast cell, exhibits anti-allergic activity. Inotodiol is orally active[1][2][3][4][5].

Product Specifications

CAS Number

35963-37-2

UNSPSC

12352211

Target

Apoptosis; Caspase; MDM-2/p53; MMP; NF-κB; p38 MAPK; SOD; Toll-like Receptor (TLR)

Type

Natural Products

Related Pathways

Apoptosis; Immunology/Inflammation; MAPK/ERK Pathway; Metabolic Enzyme/Protease; NF-κB

Applications

Cancer-programmed cell death

Field of Research

Cancer; Inflammation/Immunology; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/inotodiol.html

Purity

98.29

Solubility

10 mM in DMSO

Smiles

C[C@@]1(CC[C@@H]2O)C(CC[C@@]34C)=C(CC[C@@]1([H])C2(C)C)[C@@]3(CC[C@]4([H])[C@H](C)[C@H](O)C/C=C(C)\C)C

Molecular Formula

C30H50O2

Molecular Weight

442.72

References & Citations

[1]Nakata T, et al. Structure determination of inonotsuoxides A and B and in vivo anti-tumor promoting activity of inotodiol from the sclerotia of Inonotus obliquus. Bioorg Med Chem. 2007;15 (1) :257-264.|[2]Zhang SD, et al., Inotodiol inhibits cells migration and invasion and induces apoptosis via p53-dependent pathway in HeLa cells. Phytomedicine. 2019 Jul;60:152957.|[3]Li Y, et al. Inotodiol protects PC12 cells against injury induced by oxygen and glucose deprivation/restoration through inhibiting oxidative stress and apoptosis[J]. Journal of Applied Biomedicine, 2018, 16 (2) : 126-132.|[4]Lee SH, et al., Antiaging effect of inotodiol on oxidative stress in human dermal fibroblasts. Biomed Pharmacother. 2022 Sep;153:113311.|[5]Liu Y, et al., Inotodiol, an antiasthmatic agent with efficacy and safety, preferentially impairs membrane-proximal signaling for mast cell activation. Int Immunopharmacol. 2023 Apr;117:109854.