NNC 05-2090
NNC 05-2090 is aGABA uptake inhibitor and inhibitor of the β-GABA transporter (BGT-1) (IC50 sub>: 10.6 μM) . NNC 05-2090 also inhibits mGAT2 with a Ki value of 1.4 μM. NNC 05-2090 has anticonvulsant activity and can be used in the study of epilepsy and neurological diseases[1][2][3].
Product Specifications
CAS Number
184845-43-0
UNSPSC
12352005
Target
GABA Receptor
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/nnc-05-2090.html
Solubility
10 mM in DMSO
Smiles
OC1(CCN(CC1)CCCN2C3=C(C=CC=C3)C4=C2C=CC=C4)C5=CC=CC=C5OC
Molecular Formula
C27H30N2O2
Molecular Weight
414.54
References & Citations
[1]C Thomsen, et al. 1- (3- (9H-carbazol-9-yl) -1-propyl) -4- (2-methoxyphenyl) -4-piperidinol, a novel subtype selective inhibitor of the mouse type II GABA-transporter. Br J Pharmacol. 1997 Mar;120 (6) :983-5.|[2]N O Dalby, et al. Anticonvulsant properties of two GABA uptake inhibitors NNC 05-2045 and NNC 05-2090, not acting preferentially on GAT-1. Epilepsy Res. 1997 Jul;28 (1) :51-61.|[3]Jinzenji A, et al. Antiallodynic action of 1- (3- (9H-Carbazol-9-yl) -1-propyl) -4- (2-methyoxyphenyl) -4-piperidinol (NNC05-2090), a betaine/GABA transporter inhibitor. J Pharmacol Sci. 2014;125 (2) :217-26.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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