Metixene (hydrochloride)
Product Specifications
UNSPSC Description
Metixene (Piperidine) hydrochloride hydrate is an anticholinergic and antiparkinsonian agent. Metixene hydrochloride potently inhibits binding of quinuclidinyl benzilate (QNB) with the muscarinic receptor, IC50 and Ki values of 55 nM and 15 nM, respectively. Metixene hydrochloride can be used for the research of parkinsonian[1][2][3].
Target Antigen
Others
Type
Reference compound
Related Pathways
Others
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/metixene-hydrochloride.html
Solubility
10 mM in DMSO
Smiles
CN1CC(CC2C3=C(SC4=C2C=CC=C4)C=CC=C3)CCC1.[H]Cl
Molecular Weight
345.93
References & Citations
[1]Syvälahti EK, et al. Effects of antiparkinsonian drugs on muscarinic receptor binding in rat brain, heart and lung. Pharmacol Toxicol. 1988 Feb;62(2):90-4.|[2]J. Hagenah, et al. Exogenous levodopa is not toxic to elderly subjects with non-parkinsonian movement disorders: further clinical evidence. , 106(3-4), 301–307. doi:10.1007/s007020050159 |[3]S L Levin, et al. Dualism in the effect of cholinolytics upon the human parotid gland deprived of parasympathetic control. Int J Clin Pharmacol Res. 1986;6(5):429-39.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-120081B/Metixene-hydrochloride-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-120081B/
Clinical Information
Launched
CAS Number
1553-34-0
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