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Tyrphostin AG1112

Tyrphostin AG1112 is a potent inhibitors of CK II. Tyrphostin AG1112 inhibits p210bcr-abl tyrosine kinase, with IC50 values of 2, 15, 20 μM in p210bcr-abl, EGFR and PDGFR cells, respectively[1][2].

Product Specifications

CAS Number

153150-84-6

UNSPSC

12352005

Target

Casein Kinase; Tyrosinase

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Metabolic Enzyme/Protease; Stem Cell/Wnt

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/tyrphostin-ag1112.html

Solubility

10 mM in DMSO

Smiles

N#C/C(C1=NNC(N)=C1C#N)=C\C2=CNC3=C2C=CC=C3

Molecular Formula

C15H10N6

Molecular Weight

274.28

References & Citations

[1]T B Kang, et al. Action of 3 tyrphostin derivatives on casein kinase II from rat liver. Zhongguo Yao Li Xue Bao. 1997 Jan;18 (1) :56-8.|[2]M Anafi, et al. Tyrphostin-induced inhibition of p210bcr-abl tyrosine kinase activity induces K562 to differentiate. Blood. 1993 Dec 15;82 (12) :3524-9.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Frequently Asked Questions

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