Tyrphostin AG1112
Tyrphostin AG1112 is a potent inhibitors of CK II. Tyrphostin AG1112 inhibits p210bcr-abl tyrosine kinase, with IC50 values of 2, 15, 20 μM in p210bcr-abl, EGFR and PDGFR cells, respectively[1][2].
Product Specifications
CAS Number
153150-84-6
UNSPSC
12352005
Target
Casein Kinase; Tyrosinase
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Metabolic Enzyme/Protease; Stem Cell/Wnt
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/tyrphostin-ag1112.html
Solubility
10 mM in DMSO
Smiles
N#C/C(C1=NNC(N)=C1C#N)=C\C2=CNC3=C2C=CC=C3
Molecular Formula
C15H10N6
Molecular Weight
274.28
References & Citations
[1]T B Kang, et al. Action of 3 tyrphostin derivatives on casein kinase II from rat liver. Zhongguo Yao Li Xue Bao. 1997 Jan;18 (1) :56-8.|[2]M Anafi, et al. Tyrphostin-induced inhibition of p210bcr-abl tyrosine kinase activity induces K562 to differentiate. Blood. 1993 Dec 15;82 (12) :3524-9.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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