PF-06827443
PF-06827443 is a potent, low-clearance, orally bioavailable, and CNS-penetrant M1-selective positive allosteric modulator (PAM) with minimal agonist activity. PF-06827443 induce cholinergic AEs and convulsion[1].
Product Specifications
CAS Number
[2115022-67-6]
UNSPSC
12352005
Hazard Statement
H302-H315-H319-H335
Target
MAChR
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
COVID-19-immunoregulation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/pf-06827443.html
Solubility
10 mM in DMSO
Smiles
O=C1C2=CC(CC3=CC=C(C4=COC=N4)C=C3)=C(C)C=C2CN1[C@@H]5[C@H](COCC5)O
Molecular Formula
C24H24N2O4
Molecular Weight
404.46
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
References & Citations
[1]Jennifer E Davoren, et, al. Design and Synthesis of γ- and δ-Lactam M1 Positive Allosteric Modulators (PAMs) : Convulsion and Cholinergic Toxicity of an M1-Selective PAM with Weak Agonist Activity. J Med Chem. 2017, 60, 15.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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