Fluphenazine

Fluphenazine is a potent, orally active phenothiazine-based dopamine receptor antagonist. Fluphenazine blocks neuronal voltage-gated sodium channels. Fluphenazine acts primarily through antagonism of postsynaptic dopamine-2 receptors in mesolimbic, nigrostriatal, and tuberoinfundibular neural pathways. Fluphenazine can antagonize Methylphenidate-induced stereotyped gnawing and inhibit climbing behaviour in mice. Fluphenazine can be used for researching psychosis and painful peripheral neuropathy associated with diabetes and has potential to inhibit SARS-CoV-2[1][2][3][4][6].

Product Specifications

CAS Number

[69-23-8]

UNSPSC

12352005

Hazard Statement

H225, H301, H301+H311+H331, H370

Target

Dopamine Receptor; SARS-CoV; Sodium Channel

Type

Reference compound

Related Pathways

Anti-infection; GPCR/G Protein; Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Infection; Neurological Disease; Cancer

Assay Protocol

https://www.medchemexpress.com/fluphenazine.html

Purity

98.70

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

OCCN1CCN(CC1)CCCN2C3=C(SC4=C2C=C(C=C4)C(F)(F)F)C=CC=C3

Molecular Formula

C22H26F3N3OS

Molecular Weight

437.52

Precautions

H225, H301, H301+H311+H331, H370

References & Citations

[1]Zhou X, et al. The neuroleptic drug, fluphenazine, blocks neuronal voltage-gated sodium channels. Brain Res. 2006;1106 (1) :72-81.|[2]Nazeam J, et al. Based on Principles and Insights of COVID-19 Epidemiology, Genome Sequencing, and Pathogenesis: Retrospective Analysis of Sinigrin and ProlixinRX (Fluphenazine) Provides Off-Label Drug Candidates. SLAS Discov. 2020 Dec;25 (10) :1123-1140.|[3]Siragusa S, Bistas KG, Saadabadi A. Fluphenazine. 2022 May 8. In: StatPearls [Internet]. Treasure Island (FL) : StatPearls Publishing; 2022 Jan.|[4]Davis JL, et al. Peripheral diabetic neuropathy treated with amitriptyline and fluphenazine. JAMA. 1977 Nov 21;238 (21) :2291-2.|[5]Abdel-Hamid HA, et al. Teratogenic effect of diphenylhydantoin and/or fluphenazine in mice. J Appl Toxicol. 1996 May-Jun;16 (3) :221-5.|[6]Langwiński R, Niedzielski J. Narcotic analgesics and stereotyped behaviour in mice. Naunyn Schmiedebergs Arch Pharmacol. 1980 Jul;312 (3) :225-7.