AGK7
Product Specifications
UNSPSC Description
AGK7 is a potent inhibitor of sirtuin 2 (SIRT2). AGK7 rescues alpha-synuclein toxicity and modified inclusion morphology in a cellular model of Parkinson's disease. AGK7 protects against dopaminergic cell death both in vitro and in a Drosophila model of Parkinson's disease[1].
Target Antigen
Sirtuin
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage;Epigenetics
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/agk7.html
Solubility
10 mM in DMSO
Smiles
O=C(NC1=CC=CC2=C1N=CC=C2)/C(C#N)=C/C3=CC=C(O3)C4=CC(Cl)=CC=C4Cl
Molecular Weight
434.27
References & Citations
[1]Outeiro TF, et al. Sirtuin 2 inhibitors rescue alpha-synuclein-mediated toxicity in models of Parkinson's disease. Science. 2007;317(5837):516-519.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-119857/AGK7-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-119857/
Clinical Information
No Development Reported
CAS Number
304896-21-7
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