AGK7
AGK7 is a potent inhibitor of sirtuin 2 (SIRT2) . AGK7 rescues alpha-synuclein toxicity and modified inclusion morphology in a cellular model of Parkinson's disease. AGK7 protects against dopaminergic cell death both in vitro and in a Drosophila model of Parkinson's disease[1].
Product Specifications
CAS Number
[304896-21-7]
Product Name Alternative
SIRT2 Inhibitor, Inactive Control
UNSPSC
12352005
Target
Sirtuin
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Epigenetics
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/agk7.html
Solubility
10 mM in DMSO
Smiles
O=C(NC1=CC=CC2=C1N=CC=C2)/C(C#N)=C/C3=CC=C(O3)C4=CC(Cl)=CC=C4Cl
Molecular Formula
C23H13Cl2N3O2
Molecular Weight
434.27
References & Citations
[1]Outeiro TF, et al. Sirtuin 2 inhibitors rescue alpha-synuclein-mediated toxicity in models of Parkinson's disease. Science. 2007;317 (5837) :516-519.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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