Terrein

Terrein is a melanogenesis inhibitor[1]. Terrein induces apoptosis in breast cancer cell lines [2]. Terrein is an inhibitor of quorum sensing and c-di-GMP in Pseudomonas aeruginosa[3].

Product Specifications

CAS Number

[582-46-7]

UNSPSC

12352211

Hazard Statement

H315, H319, H320

Target

Antibiotic; Apoptosis; Melanocortin Receptor

Type

Reference compound

Related Pathways

Anti-infection; Apoptosis; GPCR/G Protein; Neuronal Signaling

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/terrein.html

Purity

99.44

Solubility

10 mM in DMSO

Smiles

O=C1C=C(/C=C/C)[C@H](O)[C@H]1O

Molecular Formula

C8H10O3

Molecular Weight

154.16

Precautions

H315, H319, H320

References & Citations

[1]S-H Park, et al. Terrein: A New Melanogenesis Inhibitor and Its Mechanism. Cell Mol Life Sci. 2004 Nov;61 (22) :2878-85.|[2]Anongnard Kasorn, et al. Terrein Inhibits Migration of Human Breast Cancer Cells via Inhibition of the Rho and Rac Signaling Pathways. Oncol Rep. 2018 Mar;39 (3) :1378-1386.|[3]Bomin Kim, et al. Terrein Is an Inhibitor of Quorum Sensing and c-di-GMP in Pseudomonas Aeruginosa: A Connection Between Quorum Sensing and c-di-GMP. Sci Rep. 2018 Jun 5;8 (1) :8617.