VU0366248

VU0366248 is a mGlu5 negative allosteric modulator[1].

Product Specifications

CAS Number

1243310-20-4

UNSPSC

12352005

Target

MGluR

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/vu0366248.html

Solubility

10 mM in DMSO

Smiles

O=C(C1=CC(F)=CC(C#N)=C1)NC2=CC=CC(Cl)=C2F

Molecular Formula

C14H7ClF2N2O

Molecular Weight

292.67

References & Citations

[1]Karen J Gregory, et al. Investigating Metabotropic Glutamate Receptor 5 Allosteric Modulator Cooperativity, Affinity, and Agonism: Enriching Structure-Function Studies and Structure-Activity Relationships. Mol Pharmacol. 2012 Nov;82 (5) :860-75.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

MGluR5

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