Gossypolone
Gossypolone is an RNA-binding protein Musashi-1 inhibitor with a Ki of 12 nM. Gossypolone disrupts the Musashi-numb RNA interaction and directly binds to the RBD1 of MSI1 protein. Gossypolone can be used for the research of cancer[1].
Product Specifications
CAS Number
[4547-72-2]
UNSPSC
12352005
Hazard Statement
H302
Target
DNA/RNA Synthesis
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/gossypolone.html
Purity
96.63
Solubility
10 mM in DMSO
Smiles
O=CC1=C(C(O)=C(C2=C1C(C(C(C3=O)=C(C(C4=C3C(C=O)=C(C(O)=C4C(C)C)O)=O)C)=C(C2=O)C)=O)C(C)C)O
Molecular Formula
C30H26O10
Molecular Weight
546.52
Precautions
H302
References & Citations
[1]Lan L, et al. Natural product derivative Gossypolone inhibits Musashi family of RNA-binding proteins. BMC Cancer. 2018 Aug 10;18 (1) :809.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, stored under nitrogen)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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