BU09059

BU09059 is a potent and selective Kappa-opioid receptor antagonist with a pA2 of 8.62. BU09059 has nanomolar affinity for the κ-receptor, with 15-fold and 616-fold selectivity over μ- and δ-receptors, respectively. BU09059 significantly blocks U50488 (HY-15997B) -induced antinociception[1].

Product Specifications

CAS Number

[1541206-05-6]

UNSPSC

12352005

Target

Opioid Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/bu09059.html

Solubility

10 mM in DMSO

Smiles

C[C@]1(C2=CC(O)=CC=C2)[C@H](CN(CC(C(OCC)=O)NC([C@H]3CC4=CC=C(O)C=C4CN3)=O)CC1)C

Molecular Formula

C28H37N3O5

Molecular Weight

495.61

References & Citations

[1]Joseph J Casal-Dominguez, et al. Characterization of BU09059: a novel potent selective κ-receptor antagonist. ACS Chem Neurosci. 2014 Mar 19;5 (3) :177-84.