BU09059
Product Specifications
UNSPSC Description
BU09059 is a potent and selective Kappa-opioid receptor antagonist with a pA2 of 8.62. BU09059 has nanomolar affinity for the κ-receptor, with 15-fold and 616-fold selectivity over μ- and δ-receptors, respectively. BU09059 significantly blocks U50488 (HY-15997B)-induced antinociception[1].
Target Antigen
Opioid Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein;Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/bu09059.html
Solubility
10 mM in DMSO
Smiles
C[C@]1(C2=CC(O)=CC=C2)[C@H](CN(CC(C(OCC)=O)NC([C@H]3CC4=CC=C(O)C=C4CN3)=O)CC1)C
Molecular Weight
495.61
References & Citations
[1]Joseph J Casal-Dominguez, et al. Characterization of BU09059: a novel potent selective κ-receptor antagonist. ACS Chem Neurosci. 2014 Mar 19;5(3):177-84.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-119733/BU09059-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-119733/
Clinical Information
No Development Reported
CAS Number
1541206-05-6
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