NNGH

NNGH is a stromelysin-1 (MMP-3) inhibitor. MMP-3 is both a direct transcriptional target and a necessary contributor of the Wnt/β-catenin signaling pathway. Matrix metalloproteinases (MMPs) play a well-defined role in later stages of tumor progression[1].

Product Specifications

CAS Number

161314-17-6

UNSPSC

12352005

Target

MMP

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/nngh.html

Purity

99.6

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

ONC(CN(CC(C)C)S(C1=CC=C(C=C1)OC)(=O)=O)=O

Molecular Formula

C13H20N2O5S

Molecular Weight

316.37

References & Citations

[1]Laurence Blavier, et al. Stromelysin-1 (MMP-3) is a target and a regulator of Wnt1-induced epithelial-mesenchymal transition (EMT) . Cancer Biol Ther. 2010 Jul 15;10 (2) :198-208.