NNGH
NNGH is a stromelysin-1 (MMP-3) inhibitor. MMP-3 is both a direct transcriptional target and a necessary contributor of the Wnt/β-catenin signaling pathway. Matrix metalloproteinases (MMPs) play a well-defined role in later stages of tumor progression[1].
Product Specifications
CAS Number
161314-17-6
UNSPSC
12352005
Target
MMP
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/nngh.html
Purity
99.6
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
ONC(CN(CC(C)C)S(C1=CC=C(C=C1)OC)(=O)=O)=O
Molecular Formula
C13H20N2O5S
Molecular Weight
316.37
References & Citations
[1]Laurence Blavier, et al. Stromelysin-1 (MMP-3) is a target and a regulator of Wnt1-induced epithelial-mesenchymal transition (EMT) . Cancer Biol Ther. 2010 Jul 15;10 (2) :198-208.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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