Simvastatin acid
Simvastatin acid (Tenivastatin), a hydrolysate of Simvastatin (HY-17502), is a HMG-CoA reductase (HMGCR) inhibitor. Simvastatin acid reduces Indoxyl sulfate-mediated reactive oxygen species (ROS) production in human cardiomyocytes. Simvastatin acid can also modulates OATP3A1 expression in cardiomyocytes and HEK293 cells transfected with the OATP3A1 gene[1][2].
Product Specifications
CAS Number
[121009-77-6]
Product Name Alternative
Tenivastatin
UNSPSC
12352211
Target
HMG-CoA Reductase (HMGCR) ; Reactive Oxygen Species (ROS)
Type
Reference compound
Related Pathways
Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB
Applications
Cancer-programmed cell death
Field of Research
Cancer; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/simvastatin-acid.html
Purity
99.66
Solubility
10 mM in DMSO
Smiles
O=C(C[C@@H](C[C@@H](CC[C@H]1[C@H](C=CC2=C[C@@H](C[C@@H]([C@]12[H])OC(C(C)(CC)C)=O)C)C)O)O)O
Molecular Formula
C25H40O6
Molecular Weight
436.58
References & Citations
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, protect from light, stored under nitrogen)
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Scientific Category
Reference compound1
Clinical Information
Launched
Available Sizes
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