Xanthopterin

Xanthopterin, an unconjugated pteridine compound, is the main component of the yellow granule in the Oriental hornet bear wings, produces a characteristic excitation/emission maximum at 386/456 nm[2]. Xanthopterin (XPT) causes renal growth and hypertrophy in rat[1]. Xanthopterin inhibits RNA synthesis[4].

Product Specifications

CAS Number

[119-44-8]

UNSPSC

12352005

Hazard Statement

H315-H319-H335

Target

DNA/RNA Synthesis

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage

Applications

COVID-19-anti-virus

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/xanthopterin.html

Solubility

10 mM in DMSO

Smiles

O=C1NC2=C(N=C1)NC(N)=NC2=O

Molecular Formula

C6H5N5O2

Molecular Weight

179.14

Precautions

P261-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P362-P403+P233-P405-P501

References & Citations

[1]Xanthopterin (XPT), an unconjugated pteridine compound, affects cell growth and differentiation. When injected into rats, XPT has caused changes that have been interpreted as renal growth and hypertrophy.|[2]Lord JL, et al. Cytotoxicity of xanthopterin and isoxanthopterin in MCF-7 cells. Cancer Lett. 2005 May 10;222 (1) :119-24.|[3]Plotkin M, et al. Xanthopterin in the Oriental hornet (Vespa orientalis) : light absorbance is increased with maturation of yellow pigment granules. Photochem Photobiol. 2009 Jul-Aug;85 (4) :955-61.|[4]Ziegler I, et al. Pterins and the regulation of lymphocyte activation on the mode of xanthopterin action. Hoppe Seylers Z Physiol Chem. 1984 Jun;365 (6) :667-73.