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Mezilamine

Mezilamine is a potent antidopaminergic agent. Mezilamine induces a concentration dependent increase in the electrically stimulated overflow of 3H-noradrenaline from rat cortical slices, without affecting the basal overflow. Mezilamine acts as a presynaptic α-adrenoceptor antagonist and a postsynaptic α-adrenoceptor agonist[1].

Product Specifications

CAS Number

50335-55-2

UNSPSC

12352005

Target

Adrenergic Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Endocrinology; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/mezilamine.html

Solubility

10 mM in DMSO

Smiles

CSC1=C(N2CCN(C)CC2)N=C(NC)N=C1Cl

Molecular Formula

C11H18ClN5S

Molecular Weight

287.81

References & Citations

[1]G Le Fur, et al. Mezilamine, a new dopamine antagonist, blocks presynaptic but stimulates postsynaptic alpha-adrenoceptors. Eur J Pharmacol. 1979 Oct 15;58 (4) :359-67.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Frequently Asked Questions

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