Mezilamine
Mezilamine is a potent antidopaminergic agent. Mezilamine induces a concentration dependent increase in the electrically stimulated overflow of 3H-noradrenaline from rat cortical slices, without affecting the basal overflow. Mezilamine acts as a presynaptic α-adrenoceptor antagonist and a postsynaptic α-adrenoceptor agonist[1].
Product Specifications
CAS Number
50335-55-2
UNSPSC
12352005
Target
Adrenergic Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Endocrinology; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/mezilamine.html
Solubility
10 mM in DMSO
Smiles
CSC1=C(N2CCN(C)CC2)N=C(NC)N=C1Cl
Molecular Formula
C11H18ClN5S
Molecular Weight
287.81
References & Citations
[1]G Le Fur, et al. Mezilamine, a new dopamine antagonist, blocks presynaptic but stimulates postsynaptic alpha-adrenoceptors. Eur J Pharmacol. 1979 Oct 15;58 (4) :359-67.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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