Melarsoprol

Melarsoprol, a melaminophenylarsine-type trivalent organic arsenical, is an important agent for African trypanosomiasis. Melarsoprol inhibits the growth of lymphoid leukemic cell by inducing apoptosis. Melarsoprol crosses the blood-brain barrier[1][2][3].

Product Specifications

CAS Number

[494-79-1]

UNSPSC

12352005

Hazard Statement

H301+H331, H410

Target

Apoptosis; Parasite

Type

Reference compound

Related Pathways

Anti-infection; Apoptosis

Applications

COVID-19-immunoregulation

Field of Research

Cancer; Infection; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/melarsoprol.html

Purity

98.0

Solubility

DMSO : 36 mg/mL (ultrasonic; warming)

Smiles

OCC1S[As](SC1)C2=CC=C(C=C2)NC3=NC(N)=NC(N)=N3

Molecular Formula

C12H15AsN6OS2

Molecular Weight

398.34

Precautions

H301+H331, H410

References & Citations

[1]Z Gregus, et al. Role of glutathione in the biliary excretion of the arsenical drugs trimelarsan and melarsoprol. Biochem Pharmacol. 2000 Jun 1;59 (11) :1375-85.|[2]König A, et al. Comparative activity of melarsoprol and arsenic trioxide in chronic B-cell leukemia lines. Blood. 1997 Jul 15;90 (2) :562-70. |[3]Ben Zirar S, et al. Comparison of nanosuspensions and hydroxypropyl-beta-cyclodextrin complex of melarsoprol: pharmacokinetics and tissue distribution in mice. Eur J Pharm Biopharm. 2008 Oct;70 (2) :649-56.