Safironil
Safironil is an antifibrotic compound. Safironil is a competitive inhibitor of collagen protein synthesis. Safironil reduces liver fibrogenesis by inhibiting HSC activation[1][2].
Product Specifications
CAS Number
134377-69-8
UNSPSC
12352005
Target
MMP
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/safironil.html
Solubility
10 mM in DMSO
Smiles
O=C(NCCCOC)C1=NC=CC(C(NCCCOC)=O)=C1
Molecular Formula
C15H23N3O4
Molecular Weight
309.36
References & Citations
[1]NO Al-Harbi, et al. Reversal of Liver Fibrosis in Chronic Murine Schistosomiasis mansoni by Safironil/Praziquantel. Tropical Journal of Pharmaceutical Research. Vol. 11 No. 4 (2012) |[2]Wang YJ, et al. Two novel antifibrotics, HOE 077 and Safironil, modulate stellate cell activation in rat liver injury: differential effects in males and females. Am J Pathol. 1998 Jan;152 (1) :279-87.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 1
Available Sizes
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