Safironil

Safironil is an antifibrotic compound. Safironil is a competitive inhibitor of collagen protein synthesis. Safironil reduces liver fibrogenesis by inhibiting HSC activation[1][2].

Product Specifications

CAS Number

[134377-69-8]

UNSPSC

12352005

Target

MMP

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/safironil.html

Solubility

10 mM in DMSO

Smiles

O=C(NCCCOC)C1=NC=CC(C(NCCCOC)=O)=C1

Molecular Formula

C15H23N3O4

Molecular Weight

309.36

References & Citations

[1]NO Al-Harbi, et al. Reversal of Liver Fibrosis in Chronic Murine Schistosomiasis mansoni by Safironil/Praziquantel. Tropical Journal of Pharmaceutical Research. Vol. 11 No. 4 (2012) |[2]Wang YJ, et al. Two novel antifibrotics, HOE 077 and Safironil, modulate stellate cell activation in rat liver injury: differential effects in males and females. Am J Pathol. 1998 Jan;152 (1) :279-87.