Acetylaszonalenin

Acetylaszonalenin, a prenylated indole derivative, is a fungal metabolite.Acetylaszonalenin is a potent neurokinin-1 (NK1) receptor antagonist. Acetylaszonalenin shows inhibition of [3H]-SP binding to human astrocytoma cells with a Ki of 170 μM[1][2].

Product Specifications

CAS Number

[42230-55-7]

Product Name Alternative

LL-S490β

UNSPSC

12352005

Target

Endogenous Metabolite; Neurokinin Receptor

Type

Natural Products

Related Pathways

GPCR/G Protein; Metabolic Enzyme/Protease; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/acetylaszonalenin.html

Solubility

10 mM in DMSO

Smiles

O=C1N2[C@@]([H])(C(NC3=CC=CC=C13)=O)C[C@]4([C@@]2(N(C5=C4C=CC=C5)C(C)=O)[H])C(C)(C=C)C

Molecular Formula

C25H25N3O3

Molecular Weight

415.48

References & Citations

[1]Wen-Bing Yin, et al. Acetylaszonalenin biosynthesis in Neosartorya fischeri. Identification of the biosynthetic gene cluster by genomic mining and functional proof of the genes by biochemical investigation. J Biol Chem. 2009 Jan 2;284 (1) :100-109.|[2]C J Barrow, et al. Spiroquinazoline, a novel substance P inhibitor with a new carbon skeleton, isolated from Aspergillus flavipes. J Nat Prod. 1994 Apr;57 (4) :471-6.