Nizofenone

Nizofenone is a neuroprotective agent which protects neurons from death following cerebral ischemia or anoxia. Nizofenone can be used in the research of acute neurological conditions, such as stroke[1][2][3].

Product Specifications

CAS Number

[54533-85-6]

UNSPSC

12352005

Target

Others

Type

Reference compound

Related Pathways

Others

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/nizofenone.html

Solubility

10 mM in DMSO

Smiles

O=C(C1=C(Cl)C=CC=C1)C2=CC([N+]([O-])=O)=CC=C2N3C=CN=C3CN(CC)CC

Molecular Formula

C21H21ClN4O3

Molecular Weight

412.87

References & Citations

[1]Yi Liu, et al. Protective effects of nizofenone administration on the cognitive impairments induced by chronic restraint stress in mice. Pharmacol Biochem Behav. 2013 Jan;103 (3) :474-80. |[2]Y Matsumoto, et al. Nizofenone, a neuroprotective drug, suppresses glutamate release and lactate accumulation. Eur J Pharmacol. 1994 Sep 1;262 (1-2) :157-61. |[3]Y Miura, et al. [Effects of nizofenone on the action potential of guinea-pig papillary muscle and S-A node and dog Purkinje fibers]. |[4]H Yasuda, et al. Cerebral protective effect and radical scavenging action. J Neurochem. 1981 Oct;37 (4) :934-8.