CHMFL-ABL-121
CHMFL-ABL-121 is a highly potent type II ABL kinase inhibitor with IC50s of 2 nM and 0.2 nM against purified inactive ABL wt and T315I kinase protein, respectively[1].
Product Specifications
CAS Number
2270879-07-5
UNSPSC
12352005
Target
Apoptosis; Bcr-Abl
Type
Reference compound
Related Pathways
Apoptosis; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/chmfl-abl-121.html
Solubility
10 mM in DMSO
Smiles
O=C(NC1=CC(C(F)(F)F)=C(CN2CCN(C)CC2)C=C1)CCSC3=CC(NN=C4/C=C/C5=CC=CC=N5)=C4C=C3
Molecular Formula
C30H31F3N6OS
Molecular Weight
580.67
References & Citations
[1]Liu X, et al. Discovery of (E) -N- (4- ((4-methylpiperazin-1-yl) methyl) -3- (trifluoromethyl) phenyl) -3- ((3- (2- (pyridin-2-yl) vinyl) -1H-indazol-6-yl) thio) propanamide (CHMFL-ABL-121) as a highly potent ABL kinase inhibitor capable of overcoming a variety of ABL mutants including T315I for chronic myeloid leukemia. Eur J Med Chem. 2018 Dec 5;160:61-81.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Abl
Frequently Asked Questions
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