BKM1644
BKM1644, an acyl-tyrosine bisphosphonate amide derivative, exhibits potent anti-cancer activity. BKM1644 effectively inhibits the proliferation of metastatic, castration-resistant prostate cance (mCRPC) cells. BKM1644 sensitizes mCRPC cells to Docetaxel and retards the bone metastatic growth of prostate cance[1].
Product Specifications
CAS Number
1070966-96-9
UNSPSC
12352005
Target
Others
Type
Reference compound
Related Pathways
Others
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/bkm1644.html
Solubility
10 mM in DMSO
Smiles
O=C(/C=C/C1=C(C(F)=C(C(F)=C1F)F)F)N[C@@H](C(NC(P(OCC)(OCC)=O)P(OCC)(OCC)=O)=O)CC2=CC=C(C=C2)OCC3=C(C=CC=C3Cl)Cl
Molecular Formula
C34H37Cl2F5N2O9P2
Molecular Weight
845.51
References & Citations
[1]Shumin Zhang, et al. Inhibition of skeletal growth of human prostate cancer by the combination of docetaxel and BKM1644: an aminobisphosphonate derivative. Oncotarget. 2016 May 10;7 (19) :27489-98.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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