TX2-121-1

1603845-42-6

12352005

Akt; EGFR; ERK; PROTACs

Reference compound

JAK/STAT Signaling; MAPK/ERK Pathway; PI3K/Akt/mTOR; PROTAC; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt

Cancer-Kinase/protease

Cancer

https://www.medchemexpress.com/tx2-121-1.html

10 mM in DMSO

C[C@@H](C(NCCN1CCC(N2C3=NC=NC(N)=C3C(C(C=C4)=CC(NC(C=C)=O)=C4OC5=CC=CC=C5)=N2)CC1)=O)CCC6(C[C@H](C7)C8)C[C@H]8C[C@H]7C6

C42H52N8O3

716.91

[1]Lim SM, et, al. Development of small molecules targeting the pseudokinase Her3. Bioorg Med Chem Lett. 2015 Aug 15;25 (16) :3382-9.

Room temperature

Reference compound1

Phase 3

ErbB3/HER3