ATM Inhibitor-10
ATM Inhibitor-10 (compound 74), a 3-quinoline carboxamide, is a highly selective and orally active ATM inhibitor (IC50: 0.6 nM) . ATM Inhibitor-10 has anti-tumor activity in SW620 xenograft models. ATM Inhibitor-10 is synergistic with Top I inhibitors[1].
Product Specifications
CAS Number
[1941214-06-7]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
ATM/ATR
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; PI3K/Akt/mTOR
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/atm-inhibitor-10.html
Purity
98.7
Solubility
10 mM in DMSO
Smiles
O=C(C1=C(N[C@H](C2=NN(C)C=C2)C)C3=CC(C4=CC=C(COC)N=C4)=C(F)C=C3N=C1)N
Molecular Formula
C23H23FN6O2
Molecular Weight
434.47
Precautions
H302, H315, H319, H335
References & Citations
[1]Degorce SL, et al. Discovery of Novel 3-Quinoline Carboxamides as Potent, Selective, and Orally Bioavailable Inhibitors of Ataxia Telangiectasia Mutated (ATM) Kinase. J Med Chem. 2016 Jul 14;59 (13) :6281-92.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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