L-641953

L-641953 is an orally active, selective TXA/PG-END receptor (thromboxane-prostaglandin endoperoxide receptor) antagonist. L-641953 significantly inhibits arachidonic acid-induced bronchoconstriction. L-641953 may be used in cardiovascular disease research[1].

Product Specifications

CAS Number

[89825-69-4]

UNSPSC

12352005

Target

Prostaglandin Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein

Applications

Neuroscience-Neuromodulation

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/l-641953.html

Solubility

10 mM in DMSO

Smiles

O=C(O)C1=CC=C(C2=C1)C=CC3=CC(F)=CC=C3[S@]2=O

Molecular Formula

C15H9FO3S

Molecular Weight

288.29

References & Citations

[1]Hall RA, et al. L-641,953 (R-8-fluoro-dibenzo[b, f]thiepin-3-carboxylic acid-5-oxide) : a novel thromboxane-prostaglandin endoperoxide antagonist. Can J Physiol Pharmacol. 1987 Apr;65 (4) :509-14.