Asukamycin

Asukamycin, a manumycin-type metabolite, could be isolated from Streptomyces nodosus subsp. asukaensis. Asukamycin is an antibiotic and has antimicrobial activity. Asukamycin inhibits growth of various tumor cell lines[1][2].

Product Specifications

CAS Number

[61116-33-4]

UNSPSC

12352005

Hazard Statement

H302

Target

Antibiotic; Bacterial; Fungal; Molecular Glues

Type

Reference compound

Related Pathways

Anti-infection; PROTAC

Applications

COVID-19-immunoregulation

Field of Research

Cancer; Infection

Assay Protocol

https://www.medchemexpress.com/asukamycin.html

Purity

95.0

Solubility

10 mM in DMSO

Smiles

O=C1[C@@H]2[C@H]([C@@](O)(C=C1NC(/C=C/C=C/C=C/C3CCCCC3)=O)/C=C/C=C/C=C/C(NC4=C(CCC4=O)O)=O)O2

Molecular Formula

C31H34N2O7

Molecular Weight

546.61

Precautions

P264-P270-P330-P501

References & Citations

[1]Shipley PR, et, al. Antitumor activity of asukamycin, a secondary metabolite from the actinomycete bacterium Streptomyces nodosus subspecies asukaensis. Int J Mol Med. 2009 Nov;24 (5) :711-5.|[2]Omura S, et, al. A new antibiotic, , asukamycin, produced by Streptomyces. J Antibiot (Tokyo) . 1976 Sep;29 (9) :876-81.