Enclomiphene (hydrochloride)

Enclomiphene ((E) -Clomiphene) hydrochloride is a potent and orally active non-steroidal estrogen receptor antagonist, with antioestrogenic property. Enclomiphene hydrochloride can be used for the research of ovarian dysfunction, testosterone deficiency, male hypogonadism and type 2 diabetes[1].

Product Specifications

CAS Number

[14158-65-7]

Product Name Alternative

(E) -Clomiphene (hydrochloride) ; trans-Clomiphene (hydrochloride) ; Enclomifene (hydrochloride)

UNSPSC

12352005

Target

Estrogen Receptor/ERR

Type

Reference compound

Related Pathways

Vitamin D Related/Nuclear Receptor

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Endocrinology; Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/enclomiphene-hydrochloride.html

Solubility

10 mM in DMSO

Smiles

Cl/C(C1=CC=CC=C1)=C(C2=CC=CC=C2)/C3=CC=C(C=C3)OCCN(CC)CC.Cl

Molecular Formula

C26H29Cl2NO

Molecular Weight

442.42

References & Citations

[1]Rodriguez KM, et al. Enclomiphene citrate for the treatment of secondary male hypogonadism. Expert Opin Pharmacother. 2016 Aug;17 (11) :1561-7. |[2]M S Opsahl, et al. Effects of enclomiphene and zuclomiphene on basal and gonadotrophin-stimulated progesterone secretion by isolated subpopulations of small and large ovine luteal cells. Hum Reprod. 1996 Jun;11 (6) :1250-5. |[3]G E Schmidt, et al. The effects of enclomiphene and zuclomiphene citrates on mouse embryos fertilized in vitro and in vivo. Am J Obstet Gynecol. 1986 Apr;154 (4) :727-36. |[4]E S Huang, et al. Estrogenic and antiestrogenic effects of enclomiphene and zuclomiphene on gonadotropin secretion by ovine pituitary cells in culture. Endocrinology. 1983 Feb;112 (2) :442-8. |[5]R Weissenberg, et al. The effect of clomiphene citrate and its Zu or En isomers on the reproductive system of the immature male rat. Andrologia. 1992 May-Jun;24 (3) :161-5. |[6]R T Turner, et al. Differential responses of estrogen target tissues in rats including bone to clomiphene, enclomiphene, and zuclomiphene. Endocrinology. 1998 Sep;139 (9) :3712-20.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

Launched

Available Sizes

Curated Selection

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