Teleocidin A1
Product Specifications
UNSPSC Description
Teleocidin A1 (Lyngbyatoxin A), a highly toxic skin irritant, is a potent activator of protein kinase C (PKC). Teleocidin A1 shows antiproliferative activity against HeLa cancer cells (IC50=9.2 nM)[1][2].
Target Antigen
PKC
Type
Natural Products
Related Pathways
Epigenetics;TGF-beta/Smad
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/teleocidin-a1.html
Solubility
10 mM in DMSO
Smiles
C/C(C)=C\CC[C@@](C)(C1=C2C3=C(C=C1)N([C@H](C(N[C@@H](CC3=CN2)CO)=O)C(C)C)C)C=C
Molecular Weight
437.62
References & Citations
[1]Stafford RG, et al. Comparison of the partition coefficient and skin penetration of a marine algal toxin (lyngbyatoxin A). Food Chem Toxicol. 1992;30(9):795-801. |[2]Youssef DT, Shaala LA, Mohamed GA, et al. 2,3-seco-2,3-dioxo-lyngbyatoxin A from a Red Sea strain of the marine cyanobacterium Moorea producens. Nat Prod Res. 2015;29(8):703-709.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-118834/Teleocidin-A1-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-118834/
Clinical Information
No Development Reported
CAS Number
70497-14-2
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