Teleocidin A1

Teleocidin A1 (Lyngbyatoxin A), a highly toxic skin irritant, is a potent activator of protein kinase C (PKC) . Teleocidin A1 shows antiproliferative activity against HeLa cancer cells (IC50=9.2 nM) [1][2].

Product Specifications

CAS Number

[70497-14-2]

Product Name Alternative

Lyngbyatoxin A

UNSPSC

12352005

Hazard Statement

H300+H310

Target

PKC

Type

Natural Products

Related Pathways

Epigenetics; TGF-beta/Smad

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/teleocidin-a1.html

Solubility

10 mM in DMSO

Smiles

C/C(C)=C\CC[C@@](C)(C1=C2C3=C(C=C1)N([C@H](C(N[C@@H](CC3=CN2)CO)=O)C(C)C)C)C=C

Molecular Formula

C27H39N3O2

Molecular Weight

437.62

Precautions

P262-P264-P270-P280-P302+P352-P330-P361+P364-P405-P501

References & Citations

[1]Stafford RG, et al. Comparison of the partition coefficient and skin penetration of a marine algal toxin (lyngbyatoxin A) . Food Chem Toxicol. 1992;30 (9) :795-801. |[2]Youssef DT, Shaala LA, Mohamed GA, et al. 2,3-seco-2,3-dioxo-lyngbyatoxin A from a Red Sea strain of the marine cyanobacterium Moorea producens. Nat Prod Res. 2015;29 (8) :703-709.