12-Oxo phytodienoic acid

12-Oxo phytodienoic acid (12-OPDA) is a plant lipid-derived anti-inflammatory compound. 12-Oxo phytodienoic acid suppresses neuroinflammation by inhibiting Nf-κB and p38 MAPK signaling in Lipopolysaccharides (LPS) (HY-D1056) -activated cells. 12-Oxo phytodienoic acid can be used for neurodegenerative diseases research[1].

Product Specifications

CAS Number

[85551-10-6]

Product Name Alternative

12-OPDA

UNSPSC

12352211

Hazard Statement

H225, H350

Target

NF-κB; p38 MAPK

Type

Reference compound

Related Pathways

MAPK/ERK Pathway; NF-κB

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/12-oxo-phytodienoic-acid.html

Concentration

3.42 mM * 100 μL in Ethanol

Purity

99.57

Solubility

10 mM in DMSO

Smiles

O=C(O)CCCCCCC[C@H]1C=CC([C@H]1C/C=C\CC)=O

Molecular Formula

C18H28O3

Molecular Weight

292.41

Precautions

H225, H350

References & Citations

[1]Taki-Nakano N, et al. 12-oxo-phytodienoic acid, a plant-derived oxylipin, attenuates lipopolysaccharide-induced inflammation in microglia. Biochem Biophys Res Commun. 2016 May 13;473 (4) :1288-1294.