12-Oxo phytodienoic acid
Product Specifications
UNSPSC Description
12-Oxo phytodienoic acid (12-OPDA) is a plant lipid-derived anti-inflammatory compound. 12-Oxo phytodienoic acid suppresses neuroinflammation by inhibiting Nf-κB and p38 MAPK signaling in LPS-activated cells. 12-Oxo phytodienoic acid can be used for neurodegenerative diseases research[1].
Target Antigen
NF-κB; p38 MAPK
Type
Reference compound
Related Pathways
MAPK/ERK Pathway;NF-κB
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/12-oxo-phytodienoic-acid.html
Purity
99.57
Solubility
10 mM in DMSO
Smiles
O=C(O)CCCCCCC[C@H]1C=CC([C@H]1C/C=C\CC)=O
Molecular Weight
292.41
References & Citations
[1]Taki-Nakano N, et al. 12-oxo-phytodienoic acid, a plant-derived oxylipin, attenuates lipopolysaccharide-induced inflammation in microglia. Biochem Biophys Res Commun. 2016 May 13;473(4):1288-1294.
Shipping Conditions
Blue Ice
Storage Conditions
Solution, -20°C, 2 years
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-118828/12-Oxo-phytodienoic-acid-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-118828/12-Oxo-phytodienoic-acid-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
85551-10-6
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