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AC-42

AC-42 is a poent M1 muscarinic selective allosteric agonist with EC50s of 805 nM and 220 nM for human wild-type and Y381A mutated M1 receptors, respectively. AC-42 stimulates the IP-accumulation and calcium mobilization in CHO cells[1][2].

Product Specifications

CAS Number

244291-63-2

UNSPSC

12352005

Target

MAChR

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/ac-42.html

Solubility

10 mM in DMSO

Smiles

O=C(CCCN1CCC(CC1)CCCC)C2=CC=CC=C2C

Molecular Formula

C20H31NO

Molecular Weight

301.47

References & Citations

[1]Marlene A Jacobson, et al. The M1 muscarinic receptor allosteric agonists AC-42 and 1-[1'- (2-methylbenzyl) -1,4'-bipiperidin-4-yl]-1,3-dihydro-2H-benzimidazol-2-one bind to a unique site distinct from the acetylcholine orthosteric site. Mol Pharmacol. 2010 Oct;78 (4) :648-57.|[2]Langmead CJ, et al., Probing the molecular mechanism of interaction between 4-n-butyl-1-[4- (2-methylphenyl) -4-oxo-1-butyl]-piperidine (AC-42) and the muscarinic M (1) receptor: direct pharmacological evidence that AC-42 is an allosteric agonist. Mol Pharmacol. 2006 Jan;69 (1) :236-46.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Frequently Asked Questions

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